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The clinical question is no longer efficacy - its access, equity, and how quickly guidelines and payers catch up with the data

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That gap in guidance is why so many people dread their weekly tirzepatide dose when, in reality, thigh injections can be the most comfortable option available

A 2025 meta-analysis of 33 placebo-controlled randomized trials involving nearly 6,000 participants found that GLP-1RAs modestly (but significantly) reduced LDL cholesterol and total cholesterol, and interestingly, weight change did not influence these lipid outcomes